Cytokine release syndrome
- G1Fever with or without constitutional symptoms
- G2Hypotension responding to fluids; hypoxia requiring low-flow nasal cannula or blow-by
- G3Hypotension managed with one pressor; hypoxia requiring high-flow nasal cannula, facemask, nonrebreather mask, or Venturi mask
- G4Life-threatening consequences; urgent intervention indicated
- G5Death
Definition and note
DefinitionA disorder characterized by fever, tachypnea, headache, tachycardia, hypotension, rash, and/or hypoxia caused by the release of cytokines.
Navigational noteConsider reporting other organ dysfunctions including neurological toxicities such as: Psychiatric disorders: Confusion, Hallucinations; Nervous system disorders: Dysphasia, Headache, Seizure, Tremor.
MedDRA code (LLT): 10052015 · CTCAE v6.0 (NCI), original English text.