CTCAE RápidoAdverse event grades · CTCAE v6.0
Código Onco

Infections and infestations

The 89 CTCAE v6.0 adverse events in Infections and infestations, with grades 1 to 5.

Abdominal infection

Infections and infestations
  1. G1Not applicable
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the abdominal cavity.

MedDRA code (LLT): 10056519 · CTCAE v6.0 (NCI), original English text.

Anorectal infection

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the anal area and the rectum.

MedDRA code (LLT): 10061640 · CTCAE v6.0 (NCI), original English text.

Appendicitis

Infections and infestations
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent.

MedDRA code (LLT): 10003011 · CTCAE v6.0 (NCI), original English text.

Appendicitis perforated

Infections and infestations
  1. G1Not applicable
  2. G2Not applicable
  3. G3Medical intervention indicated; operative intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by acute inflammation to the vermiform appendix caused by a pathogenic agent with gangrenous changes resulting in the rupture of the appendiceal wall. The appendiceal wall rupture causes the release of inflammatory and bacterial contents from the appendiceal lumen into the abdominal cavity.

MedDRA code (LLT): 10003012 · CTCAE v6.0 (NCI), original English text.

Arteritis infective

Infections and infestations
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving an artery.

MedDRA code (LLT): 10065744 · CTCAE v6.0 (NCI), original English text.

Aseptic meningitis

Infections and infestationsNew in v6.0
  1. G1Not applicable
  2. G2Not applicable
  3. G3Steroid therapy indicated; severe changes in mental status; self-limited seizure activity; neurologic abnormalities
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an inflammatory process of the meninges of the brain and/or spinal cord.

Navigational noteConsider Infections and infestations: Meningitis.

MedDRA code (LLT): 10003458 · CTCAE v6.0 (NCI), original English text.

Bacteremia

Infections and infestations
  1. G1Not applicable
  2. G2Blood culture positive with no signs or symptoms
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by the presence of bacteria in the blood stream.

Navigational noteGrade 2 with hospitalization is acceptable; Consider Infections and infestations: Sepsis (Grades 3, 4 & 5).

MedDRA code (LLT): 10003999 · CTCAE v6.0 (NCI), original English text.

Biliary tract infection

Infections and infestations
  1. G1Not applicable
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the biliary tract.

MedDRA code (LLT): 10061695 · CTCAE v6.0 (NCI), original English text.

Bladder infection

Infections and infestations
  1. G1Not applicable
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the bladder.

MedDRA code (LLT): 10005047 · CTCAE v6.0 (NCI), original English text.

Bone infection

Infections and infestations
  1. G1Not applicable
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the bones.

MedDRA code (LLT): 10061017 · CTCAE v6.0 (NCI), original English text.

Breast infection

Infections and infestations
  1. G1Not applicable
  2. G2Local infection with moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; severe infection; axillary adenitis
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the breast.

MedDRA code (LLT): 10006259 · CTCAE v6.0 (NCI), original English text.

Bronchial infection

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the bronchi.

MedDRA code (LLT): 10055078 · CTCAE v6.0 (NCI), original English text.

Candidiasis

Infections and infestationsNew in v6.0
  1. G1Asymptomatic; local symptom management indicated
  2. G2Oral intervention indicated (e.g., antifungal)
  3. G3IV antifungal intervention indicated
  4. G4Life-threatening consequences
  5. G5Death
Definition and note

DefinitionA disorder characterized by a fungal infection caused by candida.

Navigational noteIf recovered in bloodstream report as Infections and infestations: Fungemia.

MedDRA code (LLT): 10007152 · CTCAE v6.0 (NCI), original English text.

Catheter related infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process that involves a catheter or port.

Navigational noteIf related to a device other than a catheter or port, use Infections and infestations: Device related infection.

MedDRA code (LLT): 10007810 · CTCAE v6.0 (NCI), original English text.

Cecal infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the cecum.

MedDRA code (LLT): 10065761 · CTCAE v6.0 (NCI), original English text.

Cervicitis infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the uterine cervix.

MedDRA code (LLT): 10008330 · CTCAE v6.0 (NCI), original English text.

Conjunctivitis

Infections and infestations
  1. G1Asymptomatic or mild symptoms; intervention not indicated
  2. G2Symptomatic; moderate decrease in visual acuity (best corrected visual acuity 20/40 and better or 3 lines or less decreased vision from known baseline)
  3. G3Symptomatic with marked decrease in visual acuity (best corrected visual acuity worse than 20/40 or more than 3 lines of decreased vision from known baseline, up to 20/200); limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Best corrected visual acuity of 20/200 or worse in the affected eye
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by inflammation, swelling and redness to the conjunctiva of the eye.

Navigational noteConsider Infections and infestations: Conjunctivitis infective if caused by infection.

MedDRA code (LLT): 10010741 · CTCAE v6.0 (NCI), original English text.

Conjunctivitis infective

Infections and infestations
  1. G1Not applicable
  2. G2Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an infectious process involving the conjunctiva. Clinical manifestations include pink or red color in the eyes.

MedDRA code (LLT): 10010742 · CTCAE v6.0 (NCI), original English text.

Corneal infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the cornea.

MedDRA code (LLT): 10061788 · CTCAE v6.0 (NCI), original English text.

Cranial nerve infection

Infections and infestations
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving a cranial nerve.

MedDRA code (LLT): 10065765 · CTCAE v6.0 (NCI), original English text.

Cytomegalovirus infection reactivation

Infections and infestations
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated; blindness
  5. G5Death
Definition and note

DefinitionA disorder characterized by the reactivation of cytomegalovirus (CMV).

Navigational noteSynonym: CMV

MedDRA code (LLT): 10058666 · CTCAE v6.0 (NCI), original English text.

Device related infection

Infections and infestations
  1. G1Not applicable
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the use of a medical device.

Navigational noteIf related to a catheter or port, use Infections and infestations: Catheter related infection.

MedDRA code (LLT): 10064687 · CTCAE v6.0 (NCI), original English text.

Duodenal infection

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; medical intervention indicated (e.g., oral antibiotics)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the duodenum.

MedDRA code (LLT): 10065752 · CTCAE v6.0 (NCI), original English text.

Encephalitis

Infections and infestationsNew in v6.0
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; steroid therapy indicated; severe changes in mental status; self-limited seizure activity; neurologic abnormalities
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious or inflammatory process involving the brain tissue.

MedDRA code (LLT): 10014581 · CTCAE v6.0 (NCI), original English text.

Encephalomyelitis

Infections and infestationsNew in v6.0
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; steroid therapy indicated; severe changes in mental status; self-limited seizure activity; neurologic abnormalities
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious or inflammatory process involving the brain and spinal cord tissues.

MedDRA code (LLT): 10014619 · CTCAE v6.0 (NCI), original English text.

Endocarditis infective

Infections and infestations
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the endocardial layer of the heart.

MedDRA code (LLT): 10014678 · CTCAE v6.0 (NCI), original English text.

Endophthalmitis

Infections and infestations
  1. G1Not applicable
  2. G2Local intervention indicated
  3. G3Systemic intervention; hospitalization indicated
  4. G4Best corrected visual acuity of 20/200 or worse in the affected eye
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an infectious process involving the internal structures of the eye.

MedDRA code (LLT): 10014801 · CTCAE v6.0 (NCI), original English text.

Enterocolitis infectious

Infections and infestations
  1. G1Not applicable
  2. G2Passage of >3 unformed stools per 24 hrs or duration of illness >48 hrs; moderate abdominal pain; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated; profuse watery diarrhea with signs of hypovolemia; bloody diarrhea; fever; severe abdominal pain; hospitalization indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the small and/or large intestines.

Navigational noteIncludes Clostridioides difficile (c. diff, c. difficile). Consider Gastrointestinal disorders: Typhlitis, Infections and infestations: Cecal infection.

MedDRA code (LLT): 10058838 · CTCAE v6.0 (NCI), original English text.

Epstein-Barr virus infection reactivation

Infections and infestations
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by the reactivation of Epstein-Barr virus (EBV).

Navigational noteSynonym: EBV

MedDRA code (LLT): 10015109 · CTCAE v6.0 (NCI), original English text.

Esophageal infection

Infections and infestations
  1. G1Not applicable
  2. G2Local intervention indicated (e.g., oral antibiotic, antifungal, antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the esophagus.

MedDRA code (LLT): 10058804 · CTCAE v6.0 (NCI), original English text.

Eye infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated; enucleation
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the eye.

MedDRA code (LLT): 10015929 · CTCAE v6.0 (NCI), original English text.

Folliculitis

Infections and infestations
  1. G1No intervention indicated
  2. G2Topical intervention initiated
  3. G3Systemic intervention indicated
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by inflammation or infection of the hair follicles.

MedDRA code (LLT): 10016936 · CTCAE v6.0 (NCI), original English text.

Fungemia

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by the presence of fungus in the blood stream.

MedDRA code (LLT): 10017544 · CTCAE v6.0 (NCI), original English text.

Gallbladder infection

Infections and infestations
  1. G1Not applicable
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the gallbladder.

MedDRA code (LLT): 10062632 · CTCAE v6.0 (NCI), original English text.

Gum infection

Infections and infestations
  1. G1Local therapy indicated (swish and swallow)
  2. G2Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the gums.

MedDRA code (LLT): 10018784 · CTCAE v6.0 (NCI), original English text.

Hepatic infection

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the liver.

MedDRA code (LLT): 10056522 · CTCAE v6.0 (NCI), original English text.

Hepatitis B reactivation

Infections and infestations
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated; severe decompensated liver function (e.g., coagulopathy, encephalopathy, coma)
  5. G5Death
Definition and note

DefinitionA disorder characterized by the reactivation of hepatitis B virus.

MedDRA code (LLT): 10058827 · CTCAE v6.0 (NCI), original English text.

Hepatitis viral

Infections and infestations
  1. G1Asymptomatic, intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Symptomatic liver dysfunction; fibrosis by biopsy; compensated cirrhosis; hospitalization or prolongation of existing hospitalization indicated
  4. G4Life-threatening consequences; severe decompensated liver function (e.g., coagulopathy, encephalopathy, coma)
  5. G5Death
Definition and note

DefinitionA disorder characterized by a viral pathologic process involving the liver parenchyma.

MedDRA code (LLT): 10019799 · CTCAE v6.0 (NCI), original English text.

Herpes simplex reactivation

Infections and infestations
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by the reactivation of Herpes simplex virus.

MedDRA code (LLT): 10080137 · CTCAE v6.0 (NCI), original English text.

Infections and infestations - Other, specify

Infections and infestations
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

MedDRA code (LLT): 10021881 · CTCAE v6.0 (NCI), original English text.

Infective myositis

Infections and infestations
  1. G1Not applicable
  2. G2Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the skeletal muscles.

MedDRA code (LLT): 10021918 · CTCAE v6.0 (NCI), original English text.

Joint infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral); needle aspiration indicated (single or multiple)
  3. G3Arthroscopic intervention indicated (e.g., drainage) or arthrotomy (e.g., open surgical drainage)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving a joint.

MedDRA code (LLT): 10023216 · CTCAE v6.0 (NCI), original English text.

Kidney infection

Infections and infestations
  1. G1Not applicable
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the kidney.

MedDRA code (LLT): 10023424 · CTCAE v6.0 (NCI), original English text.

Laryngitis

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an inflammatory process involving the larynx.

Navigational noteFor symptoms and no intervention, consider Respiratory, thoracic and mediastinal disorders: Hoarseness, Sore throat.

MedDRA code (LLT): 10023874 · CTCAE v6.0 (NCI), original English text.

Lip infection

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an infectious process involving the lips.

MedDRA code (LLT): 10065755 · CTCAE v6.0 (NCI), original English text.

Lymph gland infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the lymph nodes.

MedDRA code (LLT): 10050823 · CTCAE v6.0 (NCI), original English text.

Mediastinal infection

Infections and infestations
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the mediastinum.

MedDRA code (LLT): 10057483 · CTCAE v6.0 (NCI), original English text.

Meningitis

Infections and infestations
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; steroid therapy indicated; severe changes in mental status; self-limited seizure activity; neurologic abnormalities
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious or inflammatory process of the meninges of the brain and/or spinal cord.

Navigational noteConsider Infections and infestations: Aseptic meningitis.

MedDRA code (LLT): 10027199 · CTCAE v6.0 (NCI), original English text.

Meningoencephalitis

Infections and infestationsNew in v6.0
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; steroid therapy indicated; severe changes in mental status; self-limited seizure activity; neurologic abnormalities
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious or inflammatory process involving the meninges and the brain tissue.

MedDRA code (LLT): 10027282 · CTCAE v6.0 (NCI), original English text.

Mucosal infection

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving a mucosal surface.

MedDRA code (LLT): 10065764 · CTCAE v6.0 (NCI), original English text.

Myelitis

Infections and infestations
  1. G1Asymptomatic; mild signs (e.g., Babinski's reflex or Lhermitte's sign)
  2. G2Moderate weakness or sensory loss; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe weakness or sensory loss; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by inflammation involving the spinal cord. Symptoms include weakness, paresthesia, sensory loss, marked discomfort and incontinence.

MedDRA code (LLT): 10028524 · CTCAE v6.0 (NCI), original English text.

Nail infection

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an infectious process involving the nail.

MedDRA code (LLT): 10061304 · CTCAE v6.0 (NCI), original English text.

Otitis externa

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the outer ear and ear canal. Contributory factors include excessive water exposure (swimmer's ear infection) and cuts in the ear canal. Symptoms include fullness, itching, swelling and marked discomfort in the ear and ear drainage.

Navigational noteChanges associated with radiation to external ear (pinnae) are graded under Injury, poisoning and procedural complications: Dermatitis radiation.

MedDRA code (LLT): 10033072 · CTCAE v6.0 (NCI), original English text.

Otitis media

Infections and infestations
  1. G1Not applicable
  2. G2Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the middle ear.

MedDRA code (LLT): 10033078 · CTCAE v6.0 (NCI), original English text.

Ovarian infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the ovary.

MedDRA code (LLT): 10055005 · CTCAE v6.0 (NCI), original English text.

Pancreas infection

Infections and infestations
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the pancreas.

MedDRA code (LLT): 10051741 · CTCAE v6.0 (NCI), original English text.

Paronychia

Infections and infestations
  1. G1Nail fold edema or erythema; disruption of the cuticle
  2. G2Local intervention indicated; oral intervention indicated (e.g., antibiotic, antifungal, antiviral); nail fold edema or erythema with pain; associated with discharge or nail plate separation; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Operative intervention indicated; IV antibiotics indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an infectious process involving the soft tissues around the nail.

MedDRA code (LLT): 10034016 · CTCAE v6.0 (NCI), original English text.

Pelvic infection

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the pelvic cavity.

MedDRA code (LLT): 10058674 · CTCAE v6.0 (NCI), original English text.

Penile infection

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the penis.

MedDRA code (LLT): 10061912 · CTCAE v6.0 (NCI), original English text.

Periorbital infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process near or around the orbit of the eye.

MedDRA code (LLT): 10051472 · CTCAE v6.0 (NCI), original English text.

Peripheral nerve infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the peripheral nerves.

MedDRA code (LLT): 10065766 · CTCAE v6.0 (NCI), original English text.

Peritoneal infection

Infections and infestations
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the peritoneum.

MedDRA code (LLT): 10057262 · CTCAE v6.0 (NCI), original English text.

Pharyngitis

Infections and infestations
  1. G1Not applicable
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by inflammation of the throat.

Navigational noteFor Grade 1 Consider Respiratory, thoracic and mediastinal disorders: Sore throat.

MedDRA code (LLT): 10034835 · CTCAE v6.0 (NCI), original English text.

Phlebitis infective

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the vein. Clinical manifestations include erythema, marked discomfort, swelling, and induration along the course of the infected vein.

MedDRA code (LLT): 10056627 · CTCAE v6.0 (NCI), original English text.

Pleural infection

Infections and infestations
  1. G1Not applicable
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the pleura.

MedDRA code (LLT): 10061351 · CTCAE v6.0 (NCI), original English text.

Pneumonia

Infections and infestationsNew in v6.0
  1. G1Not applicable
  2. G2Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the lungs.

Navigational noteReplaces Lung infection as this term is more commonly used. If due to aspiration, consider reporting Respiratory, thoracic and mediastinal disorders: Aspiration

MedDRA code (LLT): 10035664 · CTCAE v6.0 (NCI), original English text.

Prostate infection

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the prostate gland.

MedDRA code (LLT): 10050662 · CTCAE v6.0 (NCI), original English text.

Rash pustular

Infections and infestations
  1. G1Not applicable
  2. G2Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a circumscribed and elevated skin lesion filled with pus.

Navigational noteConsider Skin and subcutaneous tissue disorders: Pustular drug eruption.

MedDRA code (LLT): 10037888 · CTCAE v6.0 (NCI), original English text.

Rhinitis infective

Infections and infestations
  1. G1Not applicable
  2. G2Localized; local intervention indicated
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an infectious process involving the nasal mucosal.

MedDRA code (LLT): 10059827 · CTCAE v6.0 (NCI), original English text.

Salivary gland infection

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the salivary gland.

MedDRA code (LLT): 10039413 · CTCAE v6.0 (NCI), original English text.

Scrotal infection

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the scrotum.

MedDRA code (LLT): 10062156 · CTCAE v6.0 (NCI), original English text.

Sepsis

Infections and infestations
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV intervention indicated
  4. G4Life-threatening consequences
  5. G5Death
Definition and note

DefinitionA disorder characterized by the presence of pathogenic microorganisms in the blood stream that cause varying degrees of organ dysfunction due to a dysregulated host response to infection.

Navigational noteConsider Infections and infestations: Bacteremia (Grade 2).

MedDRA code (LLT): 10040047 · CTCAE v6.0 (NCI), original English text.

Shingles

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Local infection with moderate symptoms; oral intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; IV intervention indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by the reactivation of herpes zoster virus.

Navigational noteSynonym: Herpes zoster

MedDRA code (LLT): 10040555 · CTCAE v6.0 (NCI), original English text.

Sinusitis

Infections and infestations
  1. G1Not applicable
  2. G2Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the mucous membranes of the paranasal sinuses.

MedDRA code (LLT): 10040753 · CTCAE v6.0 (NCI), original English text.

Skin infection

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the skin such as cellulitis.

MedDRA code (LLT): 10040872 · CTCAE v6.0 (NCI), original English text.

Small intestine infection

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the small intestine.

MedDRA code (LLT): 10065771 · CTCAE v6.0 (NCI), original English text.

Soft tissue infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving soft tissues.

MedDRA code (LLT): 10062255 · CTCAE v6.0 (NCI), original English text.

Splenic infection

Infections and infestations
  1. G1Not applicable
  2. G2Not applicable
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the spleen.

MedDRA code (LLT): 10062112 · CTCAE v6.0 (NCI), original English text.

Stoma site infection

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving a stoma (surgically created opening on the surface of the body).

MedDRA code (LLT): 10064505 · CTCAE v6.0 (NCI), original English text.

Tooth infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; local intervention indicated (e.g., topical antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving a tooth.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10048762 · CTCAE v6.0 (NCI), original English text.

Tracheitis

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the trachea.

MedDRA code (LLT): 10044302 · CTCAE v6.0 (NCI), original English text.

Upper respiratory infection

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the upper respiratory tract (nose, paranasal sinuses, pharynx, larynx, or trachea).

MedDRA code (LLT): 10046300 · CTCAE v6.0 (NCI), original English text.

Urethral infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the urethra.

MedDRA code (LLT): 10052298 · CTCAE v6.0 (NCI), original English text.

Urinary tract infection

Infections and infestations
  1. G1Not applicable
  2. G2Localized; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the urinary tract, most commonly the bladder and the urethra.

MedDRA code (LLT): 10046571 · CTCAE v6.0 (NCI), original English text.

Uterine infection

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the endometrium. It may extend to the myometrium and parametrial tissues.

MedDRA code (LLT): 10062233 · CTCAE v6.0 (NCI), original English text.

Vaginal infection

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the vagina.

MedDRA code (LLT): 10046914 · CTCAE v6.0 (NCI), original English text.

Viremia

Infections and infestations
  1. G1Not applicable
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by the presence of a virus in the blood stream.

MedDRA code (LLT): 10054688 · CTCAE v6.0 (NCI), original English text.

Vulval infection

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the vulva.

MedDRA code (LLT): 10065772 · CTCAE v6.0 (NCI), original English text.

Wound infection

Infections and infestations
  1. G1Localized, local intervention indicated
  2. G2Oral intervention indicated (e.g., antibiotic, antifungal, or antiviral)
  3. G3IV antibiotic, antifungal, or antiviral intervention indicated; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by an infectious process involving the wound.

MedDRA code (LLT): 10048038 · CTCAE v6.0 (NCI), original English text.

From the same authorCódigo OncoCódigo Onco (in Portuguese): Brazilian public health system (SUS) codes for systemic cancer treatment.