CTCAE RápidoAdverse event grades · CTCAE v6.0
Código Onco

Vascular disorders

The 18 CTCAE v6.0 adverse events in Vascular disorders, with grades 1 to 5.

Arterial thromboembolism

Vascular disorders
  1. G1Not applicable
  2. G2Not applicable
  3. G3Urgent intervention indicated
  4. G4Life-threatening consequences; hemodynamic or neurologic instability; organ damage; loss of extremity(ies)
  5. G5Death
Definition and note

DefinitionA disorder characterized by occlusion of an arterial vessel by a blood clot that develops in an artery.

Navigational noteConsider Nervous system disorders: Stroke, Transient ischemic attacks for CNS-related events or Cardiac disorders: Myocardial infarction.

MedDRA code (LLT): 10073529 · CTCAE v6.0 (NCI), original English text.

Capillary leak syndrome

Vascular disorders
  1. G1Asymptomatic
  2. G2Symptomatic; medical intervention indicated
  3. G3Severe symptoms
  4. G4Life-threatening consequences
  5. G5Death
Definition and note

DefinitionA disorder characterized by leakage of intravascular fluids into the extravascular space. This syndrome is observed in patients who demonstrate a state of generalized leaky capillaries following shock syndromes, low-flow states, ischemia-reperfusion injuries, toxemias, medications, or poisoning. It can lead to generalized edema and multiple organ failure.

MedDRA code (LLT): 10007196 · CTCAE v6.0 (NCI), original English text.

Cyanosis

Vascular disorders
  1. G1Not applicable
  2. G2Present
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a bluish discoloration of the skin and/or mucous membranes.

MedDRA code (LLT): 10011703 · CTCAE v6.0 (NCI), original English text.

Flushing

Vascular disorders
  1. G1Mild symptoms; clinical or diagnostic observations only
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Symptomatic, associated with hypotension and/or tachycardia; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by episodic reddening of the skin, especially face, neck, or chest.

MedDRA code (LLT): 10016825 · CTCAE v6.0 (NCI), original English text.

Hematoma

Vascular disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Minimally invasive evacuation or aspiration indicated
  3. G3Transfusion; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a localized collection of blood, usually clotted, in an organ, space, or tissue, due to a break in the wall of a blood vessel.

Navigational noteReport subdural and epidural hematoma under Nervous system disorders: Intracranial hemorrhage.

MedDRA code (LLT): 10019428 · CTCAE v6.0 (NCI), original English text.

Hot flashes

Vascular disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Moderate symptoms; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an uncomfortable and temporary sensation of intense body warmth, flushing, sometimes accompanied by sweating upon cooling.

MedDRA code (LLT): 10020407 · CTCAE v6.0 (NCI), original English text.

Hypertension

Vascular disorders
  1. G1Not applicable
  2. G2Adult: Systolic BP 140 - 159 mmHg or diastolic BP 90 - 99 mmHg; recurrent or persistent; Pediatric and adolescent: Recurrent or persistent (>=24 hrs) BP >ULN; monotherapy indicated; systolic and /or diastolic BP between the 95th percentile and 5 mmHg above the 99th percentile; Adolescent: Systolic between 130 - 139 or diastolic between 80 - 89 even if <95th percentile
  3. G3Adult: Systolic BP 160 - 179 mmHg or diastolic BP 100 - 109 mmHg persisting over 1 hour; SBP >140 and plus either increase in SBP >20 mmHg or increase MAP >15 mmHg from baseline; Pediatric and adolescent: Systolic and/or diastolic >5 mmHg above the 99th percentile
  4. G4Adult and Pediatric: SBP≥180 or DBP ≥110 mmHg persisting over 1 hour; BP associated with acute hypertension mediated organ damage; life-threatening consequences (e.g., malignant hypertension, transient or permanent neurologic deficit, hypertensive crisis); urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a pathological increase in blood pressure.

MedDRA code (LLT): 10020772 · CTCAE v6.0 (NCI), original English text.

Hypotension

Vascular disorders
  1. G1Asymptomatic, intervention not indicated
  2. G2Non-urgent medical intervention indicated
  3. G3Medical intervention indicated; hospitalization indicated
  4. G4Life-threatening consequences and urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a blood pressure that is below the normal expected for an individual in a given environment.

MedDRA code (LLT): 10021097 · CTCAE v6.0 (NCI), original English text.

Lymph leakage

Vascular disorders
  1. G1Not applicable
  2. G2Symptomatic; medical intervention indicated
  3. G3Severe symptoms; invasive intervention indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by the loss of lymph fluid into the surrounding tissue or body cavity.

MedDRA code (LLT): 10065773 · CTCAE v6.0 (NCI), original English text.

Lymphedema

Vascular disorders
  1. G1Trace thickening or faint discoloration
  2. G2Marked discoloration; leathery skin texture; papillary formation; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by excessive fluid collection in tissues that causes swelling.

Navigational noteRecord final diagnosis/cause once determined.

MedDRA code (LLT): 10025233 · CTCAE v6.0 (NCI), original English text.

Lymphocele

Vascular disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic; medical intervention indicated
  3. G3Severe symptoms; invasive intervention indicated
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a cystic lesion containing lymph.

MedDRA code (LLT): 10048642 · CTCAE v6.0 (NCI), original English text.

Peripheral ischemia

Vascular disorders
  1. G1Not applicable
  2. G2Brief (<24 hrs) episode of ischemia managed medically and without permanent deficit; claudication
  3. G3Prolonged (>=24 hrs) or recurring symptoms and/or invasive intervention indicated; pain at rest
  4. G4Life-threatening consequences; major tissue loss; urgent operative intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by impaired circulation to an extremity.

MedDRA code (LLT): 10034578 · CTCAE v6.0 (NCI), original English text.

Phlebitis

Vascular disorders
  1. G1Not applicable
  2. G2Present
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by inflammation of the wall of a peripheral vein associated with an intravenous line.

MedDRA code (LLT): 10034879 · CTCAE v6.0 (NCI), original English text.

Superficial thrombophlebitis

Vascular disorders
  1. G1Not applicable
  2. G2Present
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by a blood clot and inflammation involving a superficial vein of the extremities.

MedDRA code (LLT): 10042554 · CTCAE v6.0 (NCI), original English text.

Superior vena cava syndrome

Vascular disorders
  1. G1Asymptomatic; incidental finding of SVC thrombosis
  2. G2Symptomatic; medical intervention indicated (e.g., anticoagulation, radiation or chemotherapy)
  3. G3Severe symptoms; multi-modality intervention indicated (e.g., anticoagulation, chemotherapy, radiation, stenting)
  4. G4Life-threatening consequences; urgent multi-modality intervention indicated (e.g., lysis, thrombectomy, surgery)
  5. G5Death
Definition and note

DefinitionA disorder characterized by obstruction of the blood flow in the superior vena cava. Signs and symptoms include swelling and cyanosis of the face, neck, and upper arms, cough, orthopnea and headache.

MedDRA code (LLT): 10042569 · CTCAE v6.0 (NCI), original English text.

Vascular disorders - Other, specify

Vascular disorders
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

MedDRA code (LLT): 10047065 · CTCAE v6.0 (NCI), original English text.

Vasculitis

Vascular disorders
  1. G1Asymptomatic, intervention not indicated
  2. G2Moderate symptoms, medical intervention indicated
  3. G3Severe symptoms, medical intervention indicated (e.g., steroids)
  4. G4Life-threatening consequences; evidence of peripheral or visceral ischemia; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by inflammation involving the wall of a vessel.

MedDRA code (LLT): 10047115 · CTCAE v6.0 (NCI), original English text.

Venous thromboembolism

Vascular disordersNew in v6.0
  1. G1Medical intervention not indicated (e.g., superficial thrombosis)
  2. G2Medical intervention indicated
  3. G3Urgent medical intervention indicated
  4. G4Life-threatening consequences with hemodynamic or neurologic instability
  5. G5Death
Definition and note

DefinitionA disorder characterized by occlusion of a vessel by a thrombus that has migrated from a distal site via the blood stream (for example, deep vein thrombosis (DVT), pulmonary embolism (PE), etc.).

Navigational noteConsider Nervous system disorders: Stroke, Transient ischemic attacks for CNS-related events. Use Vascular disorders: Arterial thromboembolism for arterial thrombi. Use Injury, poisoning and procedural complications: Vascular access complication if related to a catheter.

MedDRA code (LLT): 10066899 · CTCAE v6.0 (NCI), original English text.

From the same authorCódigo OncoCódigo Onco (in Portuguese): Brazilian public health system (SUS) codes for systemic cancer treatment.