CTCAE RápidoAdverse event grades · CTCAE v6.0
Código Onco

Endocrine disorders

The 15 CTCAE v6.0 adverse events in Endocrine disorders, with grades 1 to 5.

Adrenal insufficiency

Endocrine disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Severe symptoms; hospitalization indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by the adrenal cortex not producing enough of the hormone cortisol and in some cases, the hormone aldosterone. It may be due to a disorder of the adrenal cortex as in Addison's disease or primary adrenal insufficiency.

MedDRA code (LLT): 10001367 · CTCAE v6.0 (NCI), original English text.

Cushingoid

Endocrine disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Severe symptoms, medical intervention or hospitalization indicated
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by signs and symptoms that resemble Cushing's disease or syndrome: buffalo hump obesity, striations, adiposity, hypertension, diabetes, and osteoporosis, usually due to exogenous corticosteroids.

MedDRA code (LLT): 10011655 · CTCAE v6.0 (NCI), original English text.

Delayed puberty

Endocrine disorders
  1. G1Not applicable
  2. G2No breast development by age 13 yrs for females; testes volume of <3 cc or no Tanner Stage 2 development by age 14.5 yrs for males
  3. G3No breast development by age 14 yrs for females; no increase in testes volume or no Tanner Stage 2 by age 16 yrs for males; hormone replacement indicated
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by unusually late sexual maturity.

MedDRA code (LLT): 10012205 · CTCAE v6.0 (NCI), original English text.

Endocrine disorders - Other, specify

Endocrine disorders
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

MedDRA code (LLT): 10014698 · CTCAE v6.0 (NCI), original English text.

Hyperparathyroidism

Endocrine disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by an increase in production of parathyroid hormone by the parathyroid glands. This results in hypercalcemia (abnormally high levels of calcium in the blood).

MedDRA code (LLT): 10020705 · CTCAE v6.0 (NCI), original English text.

Hyperthyroidism

Endocrine disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic; thyroid suppression therapy indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by excessive levels of thyroid hormone in the body. Common causes include an overactive thyroid gland or thyroid hormone overdose.

MedDRA code (LLT): 10020850 · CTCAE v6.0 (NCI), original English text.

Hypogonadism

Endocrine disordersNew in v6.0
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a decrease in production of sex hormones from the gonads.

MedDRA code (LLT): 10058359 · CTCAE v6.0 (NCI), original English text.

Hypoparathyroidism

Endocrine disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Severe symptoms; medical intervention or hospitalization indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a decrease in production of parathyroid hormone by the parathyroid glands.

MedDRA code (LLT): 10021041 · CTCAE v6.0 (NCI), original English text.

Hypophysitis

Endocrine disorders
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by inflammation and cellular infiltration of the pituitary gland.

MedDRA code (LLT): 10062767 · CTCAE v6.0 (NCI), original English text.

Hypopituitarism

Endocrine disorders
  1. G1Asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated
  2. G2Moderate; minimal, local or noninvasive intervention indicated; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of existing hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a decrease in production of hormones from the pituitary gland.

Navigational noteConsider Endocrine disorders: Hypophysitis.

MedDRA code (LLT): 10021067 · CTCAE v6.0 (NCI), original English text.

Hypothyroidism

Endocrine disorders
  1. G1Asymptomatic; clinical or diagnostic observations only; intervention not indicated
  2. G2Symptomatic; thyroid replacement initiated; increase in current thyroid replacement therapy; limiting instrumental ADL or mild/moderate impact on age-appropriate normal daily activity (pediatric)
  3. G3Severe symptoms; hospitalization indicated; limiting self-care ADL or severe impact on age-appropriate normal daily activity (pediatric)
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by a decrease in production of thyroid hormone by the thyroid gland.

Navigational noteConsider Endocrine disorders: Hypophysitis.

MedDRA code (LLT): 10021114 · CTCAE v6.0 (NCI), original English text.

Precocious puberty

Endocrine disorders
  1. G1Physical signs of puberty with no biochemical markers for females <8 years and males <9 years
  2. G2Physical signs and biochemical markers of puberty for females <8 years and males <9 years
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by unusually early development of secondary sexual features; the onset of sexual maturation begins usually before age 8 for girls and before age 9 for boys.

MedDRA code (LLT): 10058084 · CTCAE v6.0 (NCI), original English text.

Testosterone deficiency

Endocrine disorders
  1. G1Asymptomatic; mild symptoms with no intervention indicated
  2. G2Replacement therapy initiated
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by low testosterone.

MedDRA code (LLT): 10067734 · CTCAE v6.0 (NCI), original English text.

Thyroiditis

Endocrine disordersNew in v6.0
  1. G1Asymptomatic
  2. G2Medical intervention indicated
  3. G3Hospitalization indicated
  4. G4Life-threatening consequences; urgent intervention indicated
  5. G5Death
Definition and note

DefinitionA disorder characterized by inflammation or destruction of the thyroid gland.

MedDRA code (LLT): 10043778 · CTCAE v6.0 (NCI), original English text.

Virilization

Endocrine disorders
  1. G1Mild symptoms; intervention not indicated
  2. G2Moderate symptoms; medical intervention indicated
  3. G3Not applicable
  4. G4Not applicable
  5. G5Not applicable
Definition and note

DefinitionA disorder characterized by inappropriate masculinization occurring in a female or prepubertal male.

MedDRA code (LLT): 10047488 · CTCAE v6.0 (NCI), original English text.

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